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MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
Published on: December 17, 2014
Normalization of cerebral vasoreactivity using BOLD MRI after intravascular stenting
Arnaud Attyé1, Marjorie Villien, Florence Tahon
1Department of Neuroradiology and MRI, University Hospital of Grenoble-IFR1, Grenoble, France; Inserm, U836, Grenoble, France; Université Joseph Fourier, Grenoble Institute of Neurosciences UMR-S836, Grenoble, France.
Human Brain Mapping
|February 22, 2013
Summary
BOLD MRI of cerebral vasoreactivity (CVR) helps identify patients with intracranial arterial stenosis needing stenting. This technique assessed vasoreactivity, guiding treatment and improving outcomes in a case study.
Area of Science:
- Neurology
- Radiology
- Cardiovascular Imaging
Background:
- Intracranial arterial stenosis treatment outcomes are controversial.
- Patient selection for angioplasty and stenting remains a challenge.
- Cerebral vasoreactivity (CVR) assessment using BOLD MRI offers reproducible brain-wide vascular reserve mapping.
Observation:
- A 63-year-old woman with severe left middle cerebral artery stenosis experienced recurrent TIAs despite medical management.
- Functional MRI (BOLD and ASL) revealed impaired vasoreactivity in the affected territory.
- The patient underwent successful intravascular stenting.
Findings:
- Post-stenting BOLD MRI CVR demonstrated normalization of vasoreactivity.
- The patient remained free of ischemic events one year after the procedure.
- BOLD MRI CVR effectively assessed the vascular reserve and treatment response.
Implications:
- BOLD MRI CVR may optimize treatment strategies for intracranial arterial stenosis.
- This imaging technique could be valuable in future therapeutic trials for stroke prevention.
- Accurate vasoreactivity assessment can improve patient selection for interventional procedures.