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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Updated: May 14, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

Nanocapsules with specific targeting and release properties using miniemulsion polymerization.

Katharina Landfester1, Volker Mailänder

  • 1Max Planck Institute for Polymer Research , Ackermannweg 10, 55128 Mainz , Germany. landfester@mpip-mainz.mpg.de

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Miniemulsion processes are versatile for creating advanced nanocarriers for drug delivery and biomedical imaging. This technique allows precise control over nanoparticle properties and payload incorporation for targeted therapeutic applications.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Nanosized materials have expanding applications in biomedicine.
  • Miniemulsion processes are highly adaptable for producing these materials for encapsulation.

Purpose of the Study:

  • To review recent developments in miniemulsion techniques for forming complex nanocarriers.
  • To highlight the adaptability of miniemulsions for encapsulating reporter molecules and drugs.

Main Methods:

  • Review of polymerization techniques within the miniemulsion process.
  • Demonstration of monomer utilization for biomedical applications.
  • Discussion of payload incorporation, including imaging markers and drugs.

Main Results:

  • Miniemulsion enables tunable control over nanoparticle size, shape, degradation, and release kinetics.
  • Both hydrophobic and hydrophilic substances can be effectively encapsulated.
  • Controlled incorporation of various payloads like MRI markers and chemotherapy drugs is achievable.

Conclusions:

  • Further research is needed on nanoparticle body distribution and intracellular degradation.
  • Understanding interactions with plasma proteins is crucial for body distribution studies.
  • Improved methodologies are required to determine intracellular degradation mechanisms of nanomaterials.