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Related Experiment Video

Updated: May 14, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Risk factors associated with craniosynostosis: a case control study.

Maryam Ardalan¹, Ali Rafati, Farideh Nejat

¹Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Pediatric Neurosurgery

|February 23, 2013

Summary

Family history of craniosynostosis and clomiphene citrate use are significant risk factors for this congenital abnormality. Further research is needed to explore environmental influences and reduce craniosynostosis occurrence.

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

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Last Updated: May 14, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Published on: November 4, 2025

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Area of Science:

Medical Genetics
Pediatric Surgery
Congenital Abnormalities

Background:

Craniosynostosis is a common congenital condition with largely unknown causes.
Identifying risk factors for craniosynostosis is crucial for understanding and potentially preventing it.

Purpose of the Study:

To investigate potential risk factors associated with craniosynostosis.
To identify independent predictors for craniosynostosis in a case-control study.

Main Methods:

A case-control study involving 70 children with craniosynostosis and 70 matched controls.
Data collected through parental interviews and checklists regarding medical history and medication use.
Analysis focused on identifying correlations between various factors and craniosynostosis.

Main Results:

The most commonly affected sutures were coronal (42.9%) and metopic (22.9%).
Maternal diabetes mellitus (11.6%) and thyroid disease (8.6%) were noted in the case group.
Mothers of affected children frequently used vitamins (94%) during pregnancy.

Conclusions:

A positive family history (OR 19.01) and clomiphene citrate use (OR 12.71) were identified as strong independent risk factors.
Further large-scale studies are necessary to confirm the role of environmental factors in craniosynostosis.
Understanding these risk factors may aid in strategies to decrease craniosynostosis incidence.