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Related Experiment Video

Updated: May 20, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk.

Wing Ki Chan1, Sofia Rasmusson1, Seyedeh Marziyeh Jabbari Shiadeh1,2

  • 1Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11, Box 432, Gothenburg, 40530, Sweden.

Cellular and Molecular Neurobiology
|May 18, 2026
PubMed
Summary

Serotonin (5-hydroxytryptamine, 5-HT) is crucial for fetal brain development and neurodevelopmental outcomes. Disrupted 5-HTergic homeostasis may increase the risk for conditions like autism spectrum disorder (ASD).

Keywords:
5-HTAutismNeurodevelopmental disorderTryptophan

Related Experiment Videos

Last Updated: May 20, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Area of Science:

  • Neurobiology
  • Developmental Neuroscience
  • Psychopharmacology

Background:

  • Serotonin (5-hydroxytryptamine, 5-HT) is a key neuromodulator influencing embryogenesis and postnatal brain maturation.
  • During pregnancy, 5-HT impacts maternal mood, placental function, and fetal brain development.
  • 5-HT acts as a developmental signal regulating neuronal proliferation, migration, and synaptic organization.

Purpose of the Study:

  • To provide an integrative framework linking 5-HT mechanisms to neurodevelopmental outcomes.
  • To examine the interplay of maternal, placental, and fetal 5-HT sources with various risk factors.
  • To explore 5-HT's role in neurodevelopmental disorders, particularly autism spectrum disorder (ASD).

Main Methods:

  • This is a narrative review integrating findings from developmental neurobiology, genetics, and psychopharmacology.
  • The review synthesizes molecular, cellular, and systems-level data on 5-HTergic signaling.
  • It considers interactions between 5-HT and genetic, environmental, and pharmacological factors during gestation.

Main Results:

  • Disrupted 5-HTergic homeostasis is proposed as a convergent mechanism underlying neurodevelopmental risk, especially for ASD.
  • Emerging evidence suggests sex-dependent 5-HTergic signaling contributes to differential offspring susceptibility.
  • Maternal, placental, and fetal 5-HT sources interact dynamically with gestational factors.

Conclusions:

  • Serotonin plays a pivotal role in neurodevelopment.
  • Altered 5-HTergic signaling is implicated in neurodevelopmental disorders like ASD.
  • 5-HT holds promise as a potential biomarker and therapeutic target for neurodevelopmental disorders.