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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Folate Receptor Alpha (FRα) and the Developing Brain: From Molecular Function to Neurodevelopmental Outcomes.

Olga Egorova1,2, Erik Domellöf3, Maryam Ardalan4,5

  • 1Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. olga.egorova@umu.se.

Molecular Neurobiology
|March 26, 2026
PubMed
Summary
This summary is machine-generated.

Folate receptor alpha (FRα) is crucial for brain development by transporting folate into the CNS. Impaired FRα function is linked to neurological and developmental disorders, necessitating further research.

Keywords:
BrainFolate receptor alphaFolate transportNeurodevelopment

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Developmental Biology

Background:

  • Folate receptor alpha (FRα) is a key transporter of folate (vitamin B9) into the central nervous system (CNS).
  • FRα plays vital roles beyond transport, including modulating signaling pathways and gene transcription.
  • Dysfunctional FRα can disrupt CNS folate availability, impacting brain development and neurological function.

Purpose of the Study:

  • To review the multifaceted roles of FRα in neuronal and glial differentiation, CNS maturation, and neural plasticity.
  • To examine the association between impaired FRα function and developmental and neuropsychiatric conditions.
  • To highlight the need for further research on FRα autoantibodies and folate supplementation therapies.

Main Methods:

  • This is a narrative review synthesizing existing knowledge on FRα.
  • Literature search and analysis of studies on FRα function and its clinical implications.
  • Examination of the connection between FRα, folate metabolism, and neurodevelopmental outcomes.

Main Results:

  • FRα is essential for delivering folate to the CNS, supporting critical metabolic pathways.
  • FRα's functions extend to regulating cellular processes and gene expression.
  • Disruptions in FRα are implicated in various developmental abnormalities and neurological dysfunctions.

Conclusions:

  • FRα is a critical regulator of cellular fate and a molecular link between folate metabolism and brain development.
  • Impaired FRα function is associated with a range of neurodevelopmental and neuropsychiatric disorders.
  • Further research is warranted to explore the diagnostic potential of FRα autoantibodies and therapeutic strategies involving folate supplementation.