Supplemental vitamin D and physical performance in COPD: a pilot randomized trial

Area of Science:

• Pulmonary Medicine
• Nutritional Science
• Geriatrics

Background:

• Low 25-hydroxyvitamin D (25[OH]D) is common in COPD patients and linked to muscle weakness.
• Vitamin D supplementation may enhance muscle strength and reduce falls in the elderly.

Purpose of the Study:

• To investigate the impact of vitamin D supplementation on physical performance in COPD patients.
• To assess if vitamin D improves physical function and respiratory quality of life.

Main Methods:

• Randomized controlled trial involving COPD patients receiving daily cholecalciferol (2000 IU) or placebo for 6 weeks.
• Primary outcome: change in Short Physical Performance Battery (SPPB) score.
• Secondary outcomes: changes in St George's Respiratory Questionnaire (SGRQ) and serum 25(OH)D levels.

Main Results:

• 36 severe COPD patients (mean age 68, Caucasian males, FEV1 33%) completed the study.
• Vitamin D increased 25(OH)D levels to a mean of 32.6 ng/mL, compared to 22.1 ng/mL in placebo.
• No significant differences were observed in SPPB or SGRQ score improvements between groups.

Conclusions:

• Daily vitamin D supplementation (2000 IU) for 6 weeks normalized 25(OH)D levels in severe COPD patients.
• Short-term vitamin D did not demonstrate a discernible effect on physical performance measures compared to placebo.