Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiographic sacroiliitis progression in psoriatic arthritis.

Rheumatology (Oxford, England)·2026
Same author

Do Patients Diagnosed with Psoriatic Arthritis Before or Concurrently with Psoriasis Have Different Disease Phenotype and Outcomes?

The Journal of rheumatology·2026
Same author

Understanding the transition from psoriasis to psoriatic arthritis: the role of targeted therapy.

EULAR rheumatology open·2026
Same author

FOXO3a Polymorphisms Are Not Associated With Axial Spondyloarthritis or Psoriatic Arthritis Susceptibility in a Canadian Cohort, With Ancestry-Specific Findings.

International journal of rheumatic diseases·2026
Same author

Body mass index and achievement of minimal disease activity in psoriatic arthritis across different classes of advanced therapy.

Rheumatology (Oxford, England)·2026
Same author

Assessing flares in patients with psoriatic arthritis using questionnaires.

RMD open·2026

Related Experiment Video

Updated: May 13, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Arthritis mutilans.

Amir Haddad1, Vinod Chandran

  • 1Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Canada.

Current Rheumatology Reports
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Arthritis mutilans, the most severe psoriatic arthritis, causes joint destruction. A new consensus definition is being developed to improve research and identify at-risk patients for early intervention.

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Related Experiment Videos

Last Updated: May 13, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

  • Rheumatology
  • Dermatology
  • Orthopedics

Background:

  • Arthritis mutilans represents the most severe manifestation of psoriatic arthritis.
  • It is characterized by digital shortening and severe osteolysis in peripheral joints.
  • Research has been hindered by the absence of a standardized case definition.

Purpose of the Study:

  • To review existing definitions, epidemiology, clinical and radiological features, and pathogenesis of arthritis mutilans.
  • To describe the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) initiative to establish a consensus definition.
  • To facilitate identification of clinical predictors and biomarkers for early detection and intervention.

Main Methods:

  • Review of current literature on arthritis mutilans definitions and features.
  • Description of the GRAPPA initiative for consensus definition development.

Main Results:

  • Existing definitions, epidemiological data, clinical and radiological characteristics, and etiological factors are presented.
  • The GRAPPA initiative aims to create a consensus definition for arthritis mutilans.

Conclusions:

  • A consensus definition is crucial for advancing research into arthritis mutilans.
  • Early identification of at-risk patients through improved definitions will enable timely therapeutic interventions.
  • Preventing joint destruction is key to preserving quality of life and function in psoriatic arthritis patients.