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Arthritis mutilans
1Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Canada.
Abstract:
Arthritis mutilans is described as the most severe form of psoriatic arthritis. It is characterized by digital shortening associated with severe osteolysis of peripheral joints. Research on arthritis mutilans has been impeded by lack of an accepted case definition. Here we describe the definitions used to date, epidemiology, clinical and radiological features, and clues to pathogenesis of arthritis mutilans. An initiative by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) to develop a consensus definition is described. The purpose of the GRAPPA initiative is to assist studies identifying clinical predictors and biomarkers for arthritis mutilans, so that patients at risk are identified early and appropriate therapeutic intervention is instituted to prevent joint destruction and preserve quality of life and function.
Insights
Arthritis mutilans, the most severe psoriatic arthritis, causes joint destruction. A new consensus definition is being developed to improve research and identify at-risk patients for early intervention.
Area of Science:
- Rheumatology
- Dermatology
- Orthopedics
Background:
- Arthritis mutilans represents the most severe manifestation of psoriatic arthritis.
- It is characterized by digital shortening and severe osteolysis in peripheral joints.
- Research has been hindered by the absence of a standardized case definition.
Purpose of the Study:
- To review existing definitions, epidemiology, clinical and radiological features, and pathogenesis of arthritis mutilans.
- To describe the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) initiative to establish a consensus definition.
- To facilitate identification of clinical predictors and biomarkers for early detection and intervention.
Main Methods:
- Review of current literature on arthritis mutilans definitions and features.
- Description of the GRAPPA initiative for consensus definition development.
Main Results:
- Existing definitions, epidemiological data, clinical and radiological characteristics, and etiological factors are presented.
- The GRAPPA initiative aims to create a consensus definition for arthritis mutilans.
Conclusions:
- A consensus definition is crucial for advancing research into arthritis mutilans.
- Early identification of at-risk patients through improved definitions will enable timely therapeutic interventions.
- Preventing joint destruction is key to preserving quality of life and function in psoriatic arthritis patients.
