Related Experiment Video

Updated: May 13, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Different activation of TRAF4 and TRAF6 in inflammatory bowel disease

Jun Shen1, Yuqi Qiao, Zhihua Ran

  • 1Key Laboratory of Gastroenterology & Hepatology of Ministry of Health and Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease and Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 1630 Dongfang Road, Shanghai 200127, China.

Mediators of Inflammation
|February 23, 2013
PubMed

Insights

Tumor necrosis factor receptor-associated factors 4 and 6 (TRAF4 and TRAF6) are overexpressed in inflammatory bowel disease (IBD). These factors play distinct roles in IBD pathogenesis, with TRAF4 indicating disease activity in ulcerative colitis (UC).

Area of Science:

  • Immunology
  • Gastroenterology
  • Molecular Biology

Background:

  • Emerging research explores tumor necrosis factor receptor-associated factor 4 (TRAF4) and TRAF6 in immune cells and mouse models.
  • TRAF4 and TRAF6 share TRAF binding sites, but their roles in inflammatory bowel disease (IBD) require comprehensive investigation.

Purpose of the Study:

  • To investigate the expression patterns and roles of TRAF4 and TRAF6 in patients with IBD.
  • To determine if TRAF4 and TRAF6 expression correlates with disease activity or specific IBD subtypes.

Main Methods:

  • Analysis of TRAF4 and TRAF6 expression in patient samples with IBD.
  • Comparison of expression patterns between inflamed and non-inflamed tissues.
  • Correlation of TRAF4 and TRAF6 levels with clinical and endoscopic disease activity.

Main Results:

  • TRAF4 and TRAF6 are significantly overexpressed in patients with IBD compared to controls.
  • TRAF4 and TRAF6 exhibit distinct expression patterns within IBD.
  • TRAF4 expression correlates with endoscopic disease activity in ulcerative colitis (UC).
  • TRAF6 preactivation is detectable in non-inflamed colonic segments of IBD patients.

Conclusions:

  • TRAF4 and TRAF6 are implicated in the pathogenesis of IBD.
  • TRAF4 and TRAF6 play differential roles in IBD development and progression.
  • TRAF4 may serve as a biomarker for endoscopic disease activity in UC.
  • TRAF6 activation occurs even in non-inflamed areas, suggesting early or widespread immune involvement.

More Related Videos

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...