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Updated: May 13, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
Published on: May 14, 2020
[Lymph transport in lymphatic nodes: mechanisms of regulation]
Abstract:
The role of lymphatic vessels in maintaining the homeostasis of tissue, lymph transport regulation and mechanisms of lymph flow is well known. Investigations of lymph node are mainly focused on processes of immune reactions and metastasis. Their role in the transport of lymph has not been almost researched; few studies have investigated the mechanisms of regulation of lymph flow in the lymph nodes. The active transport function of lymph nodes is provided by the smooth muscle contractions of the capsule of the lymph nodes. The changes of these contractions during electrical stimulation of nerve endings and effect of some biologically active substances are described in this article. The mechanisms of regulation of smooth muscle contractility and lymph nodes capsule transport functions: myogenic self-regulation, endothelium-depended and nerve regulation, regulation of histamine and heparin.
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