Related Experiment Video
Updated: May 13, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Antiseptic mouth rinses: an update on comparative effectiveness, risks and recommendations
1Full-time faculty member at the Community College of Denver Dental Hygiene Program.
Antiseptic mouth rinses, particularly those with chlorhexidine gluconate or essential oils, effectively reduce plaque and gingivitis. While generally safe, their long-term effects on dental restorations require further investigation.
Area of Science:
- Oral Health
- Periodontology
- Dental Therapeutics
Background:
- Antiseptic mouth rinses are commonly recommended for improving oral hygiene.
- Concerns exist regarding potential risks, including effects on salivary flow, oral cancer, and dental restorations.
Purpose of the Study:
- To compare the effectiveness of four commercial antiseptic mouth rinses in controlling plaque and gingivitis.
- To assess the risks associated with daily use of these mouth rinses.
Main Methods:
- Searched Google Scholar and PubMed for controlled clinical trials and systematic reviews.
- Included studies evaluating 0.12% chlorhexidine gluconate, essential oils, 0.7% cetylpyridinium chloride, and 20% aloe vera gel.
Main Results:
- Chlorhexidine gluconate and essential oil mouth rinses showed significant anti-plaque and anti-gingivitis benefits.
- Cetylpyridinium chloride offered limited benefits; aloe vera gel's effectiveness is unevaluated.
- Mouth rinses were found to be safe, with no significant impact on salivary flow. Data on restoration wear is limited.
Conclusions:
- Antiseptic mouth rinses are effective adjuncts to home care for reducing plaque and gingivitis.
- Insufficient evidence supports their role in preventing or slowing periodontitis progression.
Related Concept Videos
Hand hygiene
Hand washing...
The Oral Microbiota
Antimicrobial Effectiveness
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Tonsillitis II: Management