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Updated: May 13, 2026
18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
Single-photon emission computed tomography-computed tomography in imaging infection
Shaunak Navalkissoor1, Ewa Nowosinska, Gopinath Gnanasegaran
1Department of Nuclear Medicine, Royal Free Hospital NHS Trust, London NW3 2QG, UK. s.navalkissoor@nhs.net
Nuclear Medicine Communications
|February 26, 2013
Summary
Single-photon emission computed tomography-computed tomography (SPECT-CT) enhances infection imaging accuracy. This hybrid technology improves disease localization and assessment, aiding optimal treatment initiation.
Area of Science:
- Nuclear Medicine
- Radiology
- Medical Imaging
Background:
- Single-photon emission imaging agents for infection have long been available.
- Hybrid SPECT-CT technology has expanded the utility of these agents.
- SPECT-CT combines functional imaging with anatomical detail.
Purpose of the Study:
- To review current evidence on SPECT-CT for infection imaging.
- To evaluate the impact of SPECT-CT on diagnostic accuracy and clinical confidence.
- To assess the role of SPECT-CT in managing infectious diseases.
Main Methods:
- Review of existing literature on SPECT-CT in infection imaging.
- Analysis of commonly used radiopharmaceuticals including labeled leukocytes, Ga-67 citrate, and Tc-99m-biphosphonates.
- Evaluation of diagnostic performance improvements with SPECT-CT.
Main Results:
- SPECT-CT significantly improves accuracy in infection imaging.
- Hybrid imaging enhances specificity and defines disease location and extent.
- Fusion images increase reporting confidence across various clinical scenarios.
Conclusions:
- SPECT-CT plays a crucial role in infection imaging.
- It provides clearer assessment and accurate localization for optimized treatment.
- The technology is applicable to a broad range of clinical situations.
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