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¹Department of Biomedical Sciences, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA. howard.gelberg@oregonstate.edu

Veterinary Pathology

|February 26, 2013

Summary

A feline patient presented with rapidly developing dermal nodules. Histological examination and immunocytochemical staining confirmed feline progressive epitheliotropic dendritic cell histiocytosis.

Keywords:

CD18 epitheliotropic feline histiocytosis immunohistochemistry neoplasia skin.

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Area of Science:

Veterinary Dermatology
Oncology
Immunohistochemistry

Background:

Dendritic cell histiocytosis is a rare neoplastic proliferation of cells of the dendritic cell lineage.
Epitheliotropic forms involve the epidermis and dermis, presenting unique diagnostic challenges.

Observation:

A 10-year-old domestic short-haired cat exhibited numerous, rapidly developing, ulcerated, and crusted dermal nodules across its body.
Histological analysis revealed tightly packed polyhedral cells effacing dermal architecture with epidermal involvement.
Cellular atypia, including multinucleation and bizarre nuclei, was noted.

Findings:

The dermal mass demonstrated features consistent with epitheliotropic dendritic cell histiocytosis.
CD18 immunocytochemical staining supported the diagnosis of this specific histiocytic neoplasm.
Bacterial culture results were not detailed in the provided abstract.

Implications:

This case highlights the clinical and histological presentation of feline progressive epitheliotropic dendritic cell histiocytosis.
Accurate diagnosis relies on integrating histopathology and immunocytochemistry.
Further research may elucidate treatment strategies for this rare feline cancer.