Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 13, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Nanoparticles exposing neurotensin tumor-specific drivers.

Chiara Falciani1, Jlenia Brunetti, Barbara Lelli

  • 1Department of Medical Biotechnology, University of Siena, Siena, Italy. falciani4@unisi.it

Journal of Peptide Science : an Official Publication of the European Peptide Society
|February 26, 2013
PubMed
Summary

Branched neurotensin peptides (NT4) enhance liposome drug delivery to tumor cells more effectively than linear peptides. This targeted approach improves drug internalization and cancer cell killing, showcasing a promising advancement in drug delivery systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperative Oligomeric Peptide Combinations Enhance the Predicted Therapeutic Profile of SET-M33.

Antibiotics (Basel, Switzerland)·2026
Same author

Peptide-Based pH-Responsive MRI-CEST Agents: In Vivo Comparison between a Selected Pentapeptide and the Established Iopamidol Reference in Tumor pH Mapping Ability.

Chemical & biomedical imaging·2026
Same author

Mechanically Enhanced Ultrashort Peptide Hydrogels for pH-Triggered Release.

ACS polymers Au·2026
Same author

Poly-L-Lysine Doped FmocFF Nanogels as Delivery Platforms for siRNA.

ACS applied bio materials·2026
Same author

Establishment and application of a vesicle extraction method for clinical strains of <i>Pseudomonas aeruginosa</i>.

Microbiology spectrum·2026
Same author

Peptide-Based Nanogels for Pharmaceutical and Biotechnological Applications: From Fmoc-FF to Other Peptide Sequences.

Pharmaceuticals (Basel, Switzerland)·2026

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Nanoparticles are explored as in vivo drug carriers.
  • Bioactive markers on nanoparticles enable targeted drug delivery.
  • Low molecular weight peptides offer stability and tumor cell targeting.

Purpose of the Study:

  • To compare branched (NT4) versus linear (NT) peptides for targeting liposomes to cancer cells.
  • To evaluate the efficacy of peptide-functionalized liposomes in delivering cytotoxic drugs.
  • To determine the impact of peptide structure on liposome-cell interactions and drug delivery.

Main Methods:

  • Liposomes were functionalized with tetrabranched neurotensin peptide (NT4) or linear neurotensin peptide (NT).
  • Doxorubicin-loaded liposomes were used to assess cell binding, internalization, and cytotoxicity.

More Related Videos

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model
07:25

Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model

Published on: March 1, 2024

Related Experiment Videos

Last Updated: May 13, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model
07:25

Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model

Published on: March 1, 2024

  • Comparative analysis of branched vs. linear peptide-decorated liposomes was performed.

    • Main Results:

    • Liposomes functionalized with NT4 demonstrated improved cell binding, doxorubicin internalization, and cytotoxicity compared to non-functionalized liposomes.
    • Densely decorated liposomes with branched peptides showed a superior drug delivery activity profile.
    • The clustered presentation of branched peptides on the liposome surface facilitated enhanced cell binding and fusion.

    Conclusions:

    • Branched neurotensin peptides (NT4) are more effective than linear peptides in directing liposomes to target cancer cells.
    • Liposome functionalization with branched peptides significantly enhances drug delivery and therapeutic efficacy.
    • The structural presentation of targeting peptides is crucial for optimizing nanoparticle-based drug delivery systems.