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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels
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Published on: September 6, 2024

Mechanically Enhanced Ultrashort Peptide Hydrogels for pH-Triggered Release.

Pasqualina Liana Scognamiglio1, Carlo Diaferia2, Mariantonietta Pizzella3

  • 1Department of Basic and Applied Sciences, University of Basilicata, 85100 Potenza, Italy.

ACS Polymers Au
|June 15, 2026
PubMed
Summary

Researchers developed a pH-responsive hydrogel using ultrashort peptides. This peptide hydrogel self-assembles at physiological pH, offering tunable properties for drug delivery and soft materials.

Keywords:
drug deliverypH-Responsive hydrogelspeptide-based hydrogelsstimuli-responsive materialssupramolecular self-assembly

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Published on: September 15, 2017

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomaterials Engineering

Background:

  • Ultrashort peptide hydrogels are promising soft materials but face challenges in solubility and gelation at physiological conditions.
  • Conventional Fmoc-dipeptides like Fmoc-FF are effective hydrogelators but require precise control for injectable applications.
  • Developing injectable and in situ forming peptide hydrogels necessitates overcoming limitations in solubility and responsiveness.

Purpose of the Study:

  • To design and characterize a pH-responsive injectable hydrogel based on a novel ultrashort peptide.
  • To utilize the protonation-deprotonation equilibrium of a pyridyl moiety as a molecular switch for hydrogel formation and disassembly.
  • To investigate the potential of this hydrogel system for controlled drug release applications.

Main Methods:

  • Synthesis of a dipeptide incorporating Fmoc-β-(3-pyridyl)-l-alanine (Fmoc-3-Pal-OH).
  • Comprehensive characterization using fluorescence spectroscopy, circular dichroism, FTIR, SEM, and rheology.
  • Evaluation of pH-dependent self-assembly, mechanical properties, and drug release kinetics (curcumin).

Main Results:

  • The Fmoc-3-Pal-OH dipeptide forms hydrogels spontaneously between pH 6.0-8.0, with disassembly at acidic pH.
  • pH modulation allows fine control over nanofibrillar organization, viscoelasticity, and mechanical stability.
  • The hydrogel demonstrated high loading capacity for curcumin and sustained release at neutral pH, with accelerated release at acidic pH.

Conclusions:

  • A simple and robust molecular design strategy was achieved for pH-responsive ultrashort peptide hydrogels.
  • Protonation-controlled self-assembly overcomes limitations of conventional Fmoc-based hydrogelators.
  • These adaptable peptide networks show significant potential for stimuli-responsive soft materials and advanced drug delivery systems.