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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

[Streptococcus pneumoniae serotypes in children with chronic inflammatory diseases of the respiratory organs]

L K Katosova, T M Sidorina, A P Baturo

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |February 1, 1990
    PubMed

    Insights

    Serotypes 6, 19, and 15 were most common in children with chronic bronchopulmonary diseases. New exacerbations were linked to different pneumococcal serotypes, with some penicillin resistance noted, particularly in serogroup 19.

    Area of Science:

    • Microbiology
    • Pediatrics
    • Epidemiology

    Background:

    • Chronic bronchopulmonary diseases in children are often associated with pneumococcal infections.
    • Understanding pneumococcal serotype prevalence is crucial for disease management and vaccine development.

    Purpose of the Study:

    • To investigate the serotype distribution of Streptococcus pneumoniae strains in children with chronic bronchopulmonary diseases.
    • To analyze temporal and regional variations in pneumococcal serotypes.
    • To assess the relationship between pneumococcal serotype and disease exacerbations, and to identify antibiotic resistance patterns.

    Main Methods:

    • Longitudinal study over 7 years (1982-1988).
    • Isolation and serotyping of 276 pneumococcal strains from pediatric patients.
    • Regional analysis of serotype circulation.
    • Assessment of penicillin resistance.

    Main Results:

    • Serotypes 6, 19, and 15 were the most prevalent, accounting for half of all isolates.
    • Periodic fluctuations in serotype occurrence were observed.
    • Regional variations in serotype distribution were identified, with serogroups 6 and 19 being common.
    • New exacerbations of chronic bronchopulmonary disease were associated with different pneumococcal serotypes.
    • Penicillin-resistant strains (3.4%) and sensitive strains (1.8%) were detected, with most resistant strains belonging to serogroup 19.

    Conclusions:

    • Pneumococcal serotype composition in children with chronic bronchopulmonary diseases is dynamic and shows regional variations.
    • The association of different serotypes with disease exacerbations suggests a complex etiological relationship.
    • The presence of penicillin resistance, particularly in serogroup 19, highlights the need for ongoing surveillance and appropriate treatment strategies.

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