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Updated: May 13, 2026
17:59
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Published on: April 3, 2011
Thymic and pulmonary mucosa-associated lymphoid tissue lymphomas
Takashi Muramatsu1, Yoko Tanaka, Ryota Higure
1Department of Surgery, Nihon University School of Medicine, Tokyo, Japan. mura@med.nihon-u.ac.jp
The Annals of Thoracic Surgery
|February 27, 2013
Summary
Multiorgan mucosa-associated lymphoid tissue (MALT) lymphoma, a rare cancer, can develop without autoimmune diseases. This case highlights MALT lymphoma in the thymus and lung without prior autoimmune conditions.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with autoimmune conditions like Sjogren's syndrome.
- Multiorgan involvement of MALT lymphoma is uncommon and its pathogenesis in the absence of autoimmunity is not well understood.
Observation:
- A 52-year-old woman presented with a mediastinal tumor and right lung opacity.
- Diagnostic procedures included tumor resection and fine needle aspiration of pulmonary tissue.
- Histopathologic and cytologic analyses were performed.
Findings:
- Both the thymus tumor and lung tissue were diagnosed as mucosa-associated lymphoid tissue (MALT) lymphoma.
- Immunohistochemistry confirmed the MALT lymphoma diagnosis.
Implications:
- This case demonstrates that multiorgan MALT lymphoma can occur independently of autoimmune diseases.
- It expands the understanding of MALT lymphoma's potential clinical presentations and etiological factors.
- Further research may elucidate the mechanisms driving MALT lymphoma development in non-autoimmune settings.
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