Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

Phagocytosis of Apoptotic Cells

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling.

Nature communications·2026

Same author

Expert opinion on burning questions in cancer myeloid cell biology.

Journal for immunotherapy of cancer·2026

Same author

Harnessing myeloid cell plasticity for cancer therapy.

Nature cancer·2026

Same author

A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma.

Cell reports. Medicine·2026

Same author

From controversy to opportunity: experts weigh in on myeloid states as determinants in cancer immunotherapy.

Journal for immunotherapy of cancer·2026

Same author

TMEM33 deletion potentiates anti-tumor CD8<sup>+</sup> T cell immunity.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Applying pressure on macrophages.

Dmitry I Gabrilovich¹

¹H. Lee Moffitt Cancer Center and Research Institute, MRC 2067, 12902 Magnolia Dr., Tampa, FL 33647, USA. dmitry.gabrilovich@moffitt.org

|February 27, 2013

Summary

Increased angiotensin II in tumor-bearing mice drives macrophage progenitor expansion and supply. This finding reveals a key mechanism linking the tumor microenvironment to immune cell dynamics.

Area of Science:

Immunology
Cancer Biology
Tumor Microenvironment

Background:

Tumor growth is associated with altered immune cell populations.
The role of specific molecular signals in regulating immune cell supply within tumors requires further elucidation.

Discussion:

Cortez-Retamozo et al. show that elevated angiotensin II levels in tumor-bearing mice promote the expansion of macrophage progenitors.
This process enhances the overall supply of macrophages within the tumor microenvironment.

Key Insights:

Angiotensin II acts as a critical mediator in tumor-associated immune cell recruitment.
The study identifies a novel pathway by which tumors manipulate host immune cell production.

Outlook:

More Related Videos

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages

In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages

Published on: December 30, 2017

Related Experiment Videos

Last Updated: May 13, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages

In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages

Published on: December 30, 2017

Further research can explore therapeutic strategies targeting the angiotensin II pathway to modulate macrophage populations in cancer.

Understanding these mechanisms could lead to new immunotherapeutic approaches for cancer treatment.