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Published on: June 28, 2021
Acute pancreatitis is associated with Ser608Leu iNOS polymorphism
1Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Faculty of Medicine, Istanbul University, Istanbul, Turkey. gulozhan@istanbul.edu.tr
The inducible nitric oxide synthase (iNOS) Ser608Leu gene polymorphism is associated with an increased risk of acute pancreatitis. This finding suggests iNOS Ser608Leu may serve as a valuable risk marker for this inflammatory condition.
Area of Science:
- Genetics
- Molecular Biology
- Gastroenterology
Background:
- Acute pancreatitis is an inflammatory condition of the pancreas with incompletely understood mechanisms.
- Inflammatory pathways involving cytokines are crucial in acute pancreatitis.
- The inducible nitric oxide synthase (iNOS) gene plays a role in inflammation and nitric oxide production.
Purpose of the Study:
- To investigate the association between acute pancreatitis risk and single-nucleotide polymorphisms (SNPs) in the iNOS gene.
- To evaluate specific iNOS SNPs: Ser608Leu, 1173C/T, and 954G/C.
Main Methods:
- Genotyping of three iNOS SNPs (Ser608Leu, 1173C/T, 954G/C) in 93 acute pancreatitis patients and 60 controls.
- Age and gender-matched control group.
- Statistical analysis using conditional logistic regression.
Main Results:
- The Ser608Leu polymorphism was significantly more frequent in acute pancreatitis patients compared to controls (OR = 2.88; P = 0.002).
- No statistically significant associations were found for the 1173C/T and 954G/C SNPs individually.
- The Ser608Leu variant was linked to increased risk.
Conclusions:
- The iNOS Ser608Leu polymorphism may be a useful genetic marker for assessing acute pancreatitis risk.
- Further research is warranted to elucidate the precise role of iNOS in pancreatitis pathogenesis.
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