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Serum prolactin levels during extended cocaine abstinence
1Department of Psychiatry, University of Health Sciences/Chicago Medical School, IL 60064.
The American Journal of Psychiatry
|June 1, 1990
Summary
Cocaine abstinence does not cause high prolactin levels in most users. This study found a low incidence of hyperprolactinemia, suggesting other medical causes for elevated prolactin.
Area of Science:
- Endocrinology
- Neuropharmacology
- Addiction Medicine
Background:
- Previous reports suggested a near 100% risk of hyperprolactinemia after one month of cocaine abstinence.
- Hyperprolactinemia is a condition characterized by abnormally high levels of prolactin in the blood.
Purpose of the Study:
- To investigate the actual incidence of hyperprolactinemia in individuals abstaining from cocaine.
- To determine if cocaine abstinence itself is a cause of elevated serum prolactin levels.
Main Methods:
- Serum prolactin concentrations were measured in 23 male inpatients.
- Patients had abstained from cocaine use for a duration ranging from 2 to 43 weeks.
Main Results:
- None of the 23 male inpatients exhibited elevated serum prolactin levels.
- The incidence of hyperprolactinemia was determined to be below 12.3% with 95% confidence.
Conclusions:
- Cocaine abstinence alone is unlikely to be the sole cause of persistent hyperprolactinemia.
- Elevated prolactin levels in former cocaine users warrant further medical investigation for other underlying conditions.