Related Experiment Video
Updated: May 13, 2026
05:23
Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
Published on: April 14, 2026
Regeneration of condyle with a functional appliance
T Fujita1, H Hayashi, M Shirakura
1Department of Orthodontics and Craniofacial Developmental Biology, Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. seven@ hiroshima-u.ac.jp
Journal of Dental Research
|February 27, 2013
Summary
Functional appliances aid condylar regeneration after surgery in rats. This promotes mandibular growth and restores symmetrical chewing muscle activity, improving functional recovery.
Area of Science:
- Regenerative medicine
- Oral and Maxillofacial Surgery
- Biomedical Engineering
Background:
- Condylectomy, the surgical removal of the mandibular condyle, presents challenges in restoring jaw function.
- Functional appliances have shown promise in aiding condylar regeneration, but the underlying processes require further elucidation.
- Understanding the temporal dynamics of condylar regeneration and its impact on mandibular growth and muscle activity is crucial for optimizing treatment outcomes.
Purpose of the Study:
- To investigate the process of condylar regeneration following unilateral condylectomy in growing rats.
- To evaluate the effects of functional appliance use on mandibular growth and masticatory muscle activity during and after condylar regeneration.
- To determine the morphological and functional recovery of the mandibular condyle after treatment with functional appliances.
Main Methods:
- Seventy-five male Wistar rats were divided into three groups: unilateral condylectomy, unilateral condylectomy with a functional appliance, and a control group.
- The study monitored condylar morphology, mandibular growth, and masticatory muscle activity over an 8-week period post-surgery.
- Functional appliances were applied immediately after unilateral condylectomy in the treatment group.
Main Results:
- Functional appliance use significantly promoted mandibular growth and initiated condylar regeneration within 1 week after condylectomy.
- Normal condylar morphology was achieved by 8 weeks post-condylectomy in the appliance group.
- While condylectomy induced asymmetrical masticatory muscle activity, the functional appliance facilitated the restoration of symmetrical muscle function.
Conclusions:
- Functional appliances play a vital role in promoting favorable condylar regeneration and mandibular growth after condylectomy.
- The use of functional appliances leads to the recovery of symmetrical masticatory muscle activity, suggesting a restoration of balanced jaw function.
- These findings highlight the therapeutic potential of functional appliances in managing the consequences of condylectomy and enhancing functional recovery.
More Related Videos
08:58Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
09:26An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
Related Concept Videos
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:07Development of the Limb Synovial Joints
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:27Growth of Cartilage and Bone Tissue
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...