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Related Concept Videos

Capillaries and Their Types01:20

Capillaries and Their Types

Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists, with...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

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Related Experiment Video

Updated: May 13, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
05:06

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

[Capillaroscopy. An update].

J Richter1, C Iking-Konert, M Schneider

  • 1Poliklinik für Rheumatologie, Heinrich Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Zeitschrift Fur Rheumatologie
|February 27, 2013
PubMed
Summary
This summary is machine-generated.

Standardized capillaroscopy training has improved diagnostic agreement among rheumatologists. This technique is crucial for diagnosing systemic sclerosis and Raynaud's disease, with new tools enhancing its application.

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A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy

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Related Experiment Videos

Last Updated: May 13, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
05:06

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy
05:17

A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy

Published on: October 27, 2015

Area of Science:

  • Rheumatology
  • Medical Diagnostics
  • Microscopy

Context:

  • Two years post-German consensus on capillaroscopy nomenclature and procedures.
  • Over 300 rheumatologists nationwide completed certified training.
  • Standardization efforts aim to improve inter-observer agreement in capillaroscopy findings.

Purpose:

  • To report innovations and advancements in capillaroscopy following the German consensus.
  • To evaluate the impact of standardized training on diagnostic accuracy.
  • To assess the evolving role of capillaroscopy in diagnosing and managing rheumatic diseases.

Summary:

  • Certified training courses have significantly increased nationwide, leading to better agreement on capillaroscopy findings among rheumatologists.
  • The number of capillaroscopy-related publications has surged, with studies focusing on systemic sclerosis, Raynaud's disease, and systemic lupus erythematosus.
  • A large European study validated the Capillaroscopic Skin Ulcer Risk Index (CSURI), confirming capillaroscopy's role as a screening tool.

Impact:

  • Capillaroscopy is now indispensable for diagnosing Raynaud's disease and early systemic sclerosis.
  • The technique is increasingly utilized in the diagnostic work-up for systemic lupus erythematosus.
  • Advancements include the growing use of videocapillaroscopy and USB microscopes alongside traditional methods.