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Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
Published on: May 26, 2023
Current devices for pediatric extracorporeal life support and mechanical circulatory support systems in the United
1Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA 17033-0850, USA. aundar@psu.edu
Insights
Extracorporeal life support (ECLS) and mechanical circulatory support (MCS) are vital for pediatric heart defects. This review covers current ECLS and MCS devices in the US for treating heart and lung failure in children.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Surgery
- Biomedical Engineering
Background:
- Extracorporeal life support (ECLS) and mechanical circulatory support (MCS) are critical interventions for pediatric patients with congenital heart defects experiencing heart or lung failure.
- These support systems serve as crucial bridges to recovery, transplantation, destination therapy, or long-term mechanical support.
Purpose of the Study:
- To review and discuss the currently available devices for pediatric ECLS and MCS in the United States.
- To highlight the importance of appropriate device selection and cannulation strategies in pediatric patients.
Main Methods:
- Literature review of current ECLS and MCS devices used in pediatric care.
- Discussion of device selection criteria based on patient condition and support type (e.g., V-A ECMO, V-V ECMO, uni-/biventricular MCS).
Main Results:
- Various ECLS and MCS devices are available for pediatric use, offering tailored support for different failure types.
- Careful consideration of patient size, access sites, cannulation, and equipment (tubing, oxygenator, pump) is essential for optimal outcomes.
- Proper device selection minimizes injury and facilitates early support, reducing device-related complications.
Conclusions:
- The appropriate selection and application of ECLS and MCS devices are paramount for successful management of pediatric heart and lung failure.
- Optimizing device characteristics and cannulation techniques improves patient outcomes and reduces morbidity and mortality in this vulnerable population.
Abstract:
Extracorporeal life support (ECLS) and mechanical circulatory support (MCS) have become indispensable treatment tools for pediatric patients with congenital heart defects undergoing peri-operative or end-stage heart and/or lung failure. ECLS and MCS can serve as bridges to recovery, transplantation (heart or lung), destination therapy, or "bridge to bridge" long-term MCS. Dependent on patient condition, venoarterial ECMO (V-A ECMO) for heart and lung support, venovenous ECMO (V-V ECMO) for respiratory support, and MCS for uni- and biventricular support can be selected properly. Considering small patient body size, the access sites and cannulation should be selected carefully to obtain adequate blood flow, minimum injury, and easy management. The applying equipment, including tubing, cannulae, oxygenator and blood pump, need to be selected optimally in order to enable rapid setup and priming, successful cannulation and early support, and to reduce the risk of device-related morbidity and mortality. The aim of this review manuscript was to discuss briefly the current devices for pediatric ECLS and MCS available in US.
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