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Genetic changes with prognostic value in histologically benign meningiomas.
Sandra Barbera1, Teresa San Miguel, Rosario Gil-Benso
1Department of Pathology, University of Valencia, Valencia, Spain.
Clinical Neuropathology
|February 28, 2013
Summary
Cytogenetic alterations in chromosomes 1p and 14 may indicate higher recurrence risk in benign meningiomas. These findings help predict tumor aggressiveness and recurrence potential in patients.
Area of Science:
- Neuro-oncology
- Genetics
- Pathology
Background:
- Meningiomas represent up to 25% of intracranial tumors.
- Predicting the aggressiveness of histologically benign meningiomas remains challenging.
- Understanding prognostic markers is crucial for patient management.
Purpose of the Study:
- To investigate the prognostic value of chromosomal aberrations in chromosomes 1p, 14, and 22.
- To correlate these genetic alterations with tumor progression and recurrence risk in meningiomas.
- To differentiate benign meningiomas with higher recurrence potential.
Main Methods:
- Histopathological analysis of meningiomas according to WHO criteria.
- Fluorescence in situ hybridization (FISH) to detect chromosomal aberrations (1p, 14, 22).
- Analysis of 70 patient cases, including benign, atypical, and anaplastic meningiomas.
Main Results:
- Benign meningiomas showed various chromosomal alterations, including monosomy 22 (36%) and 1p deletion (10%).
- Higher-grade meningiomas (Grade II and III) frequently exhibited alterations in chromosome 14 (67% and 100%, respectively).
- Recurrence rates were significantly higher in tumors with 1p and 14 abnormalities (90% of recurrent cases).
Conclusions:
- Cytogenetic analysis, particularly of chromosomes 1p and 14, can identify benign meningiomas with increased risk of recurrence.
- Benign meningiomas with these specific alterations may share characteristics with atypical meningiomas.
- These findings enhance prognostic accuracy for meningioma patients.
