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Hydrogen peroxide alters sternohyoid muscle function
1UCD School of Medicine and Medical Science, Health Sciences, University College Dublin, Dublin, Ireland.
Oral Diseases
|March 1, 2013
Summary
Hydrogen peroxide (H2O2) impairs upper airway muscle endurance, potentially contributing to airway collapse in conditions like obstructive sleep apnea (OSA). Antioxidants partially reversed these effects, suggesting a role for oxidative stress.
Area of Science:
- Physiology
- Respiratory Muscle Function
- Oxidative Stress
Background:
- Upper airway (UA) dilator muscles maintain airway patency.
- Dysfunction of these muscles, seen in obstructive sleep apnea (OSA), can lead to UA collapse.
- Increased reactive oxygen species (ROS) are implicated in muscle dysfunction.
Purpose of the Study:
- To investigate the impact of hydrogen peroxide (H2O2) on rat sternohyoid muscle function.
- To explore the role of oxidants in upper airway muscle fatigue and dysfunction.
Main Methods:
- In vitro assessment of rat sternohyoid muscle contractile and endurance properties.
- Exposure to varying concentrations of H2O2 (0-1 mM) under normoxic and hypoxic conditions.
- Testing the effects of antioxidants (desferoxamine, catalase) and dithiothreitol (DTT).
Main Results:
- H2O2 reduced sternohyoid muscle endurance in a dose-dependent manner.
- Antioxidants and DTT partially mitigated the H2O2-induced decrease in muscle endurance.
- Hypoxia exacerbated the effects of H2O2 on muscle function.
Conclusions:
- Oxidative stress contributes to upper airway dilator muscle dysfunction.
- These findings have implications for understanding airway patency control in vivo.
- Targeting oxidative stress may be a potential therapeutic strategy for OSA-related muscle dysfunction.
Keywords:
fatiguehydrogen peroxideobstructive sleep apnoeareactive oxygen speciesupper airway musclesMore Related Videos
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