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Updated: May 13, 2026
08:11
Quantitative Analysis of Chromatin Proteomes in Disease
Published on: December 28, 2012
Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics
Kiersten A Liddy1, Melanie Y White2, Stuart J Cordwell2
1School of Molecular Bioscience, The University of Sydney, 2006 Sydney, Australia.
Genome Medicine
|March 1, 2013
Summary
Post-translational modifications (PTMs) significantly alter protein function and are crucial for cell signaling. Proteomics helps study how PTMs contribute to the molecular mechanisms underlying various heart diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Research
Background:
- Over 300 post-translational modifications (PTMs) exist, altering protein structure and function.
- PTMs enable rapid signal transmission and regulation in response to stimuli.
- PTMs are implicated in diverse heart disease states, including acute, chronic, and genetic conditions.
Purpose of the Study:
- To discuss the utility of proteomics in examining PTMs.
- To explore the role of PTMs in the molecular mechanisms of heart disease.
Main Methods:
- Proteomics approaches are utilized to investigate PTMs.
- Analysis of reversible and irreversible PTMs in disease contexts.
Main Results:
- PTMs can be stable/irreversible (e.g., aging, injury) or transient (e.g., signaling).
- Interplay between different PTMs can influence cellular function through cooperation or competition.
- Specific PTMs are associated with various heart conditions like heart failure and cardiomyopathy.
Conclusions:
- Proteomics is a valuable tool for understanding PTMs in heart disease.
- Investigating PTMs offers insights into the molecular basis of cardiovascular pathologies.
- Understanding PTMs may reveal novel therapeutic targets for heart disease.
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