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Related Experiment Video

Updated: May 13, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Experimental Model of Ligature-Induced Peri-Implantitis in Mice

Published on: May 17, 2024

Tissue ingrowth into perforated polymethylmethacrylate orbital implants: an experimental study.

Denise Miyashita1, Fernando Chahud, Gyl Eanes Barros da Silva

  • 1Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas-Campus, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Ophthalmic Plastic and Reconstructive Surgery
|March 1, 2013
PubMed
Summary

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Perforated acrylic orbital implants showed successful fibrovascular ingrowth and good clinical response in a rabbit model. These implants are a viable option for orbital reconstruction, similar to porous materials.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Orbital implants are crucial for restoring ocular volume after evisceration.
  • Conventional implants may have limitations in achieving optimal tissue integration.

Purpose of the Study:

  • To assess the clinical performance and tissue integration of novel perforated acrylic orbital implants.
  • To compare the efficacy of perforated implants with existing porous orbital implant materials.

Main Methods:

  • Perforated acrylic spheres (12-13 mm) with interconnected channels were surgically implanted in rabbit orbits.
  • Clinical assessments were conducted daily for 14 days, then weekly up to 180 days.
  • Histopathological analysis (H&E, Picrosirius red) evaluated tissue ingrowth, inflammation, and collagen deposition at multiple time points.

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

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Last Updated: May 13, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
05:37

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Main Results:

  • No infections, exposures, or extrusions were observed throughout the 180-day study period.
  • Significant fibrovascular tissue ingrowth into the implant's central channels was evident by day 14.
  • Dense collagen deposition with minimal inflammation was noted at study completion, with no giant cells.

Conclusions:

  • Perforated acrylic orbital implants facilitate robust fibrovascular ingrowth, comparable to porous implants.
  • These implants demonstrate excellent clinical tolerance and tissue integration, offering a promising alternative for orbital reconstruction.