Related Experiment Video
Updated: Apr 21, 2026
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Intravitreal Bevacizumab plus Methotrexate for iris and ciliary body metastasis from lung cancer
Thaís Marino de Azeredo Bastos1, Igor Neves Coelho1, Leticia Audi1
1Departments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Purpose:
To describe a case of iris and ciliary body metastasis from lung adenocarcinoma responding to intravitreal bevacizumab and methotrexate.
Observations:
A 66-year-old man presented with an amelanotic vascular lesion of the iris and ciliary body (7 × 4 mm, 4 mm thick). Fine-needle aspiration biopsy confirmed lung adenocarcinoma. After intravitreal bevacizumab and methotrexate, the tumor showed marked regression within 2 months.
Conclusions:
Intravitreal bevacizumab combined with methotrexate may represent a minimally invasive alternative to radiation therapy for ocular metastases.
