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Paraneoplastic vitelliform retinopathy successfully treated with intravitreal dexamethasone implants
Mariel S Natividade1, Victor Bellanda1,2, Gabriela M Carvalho1
1Ophthalmology Division, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
American Journal of Ophthalmology Case Reports
|March 19, 2026
Summary
A rare case of paraneoplastic vitelliform retinopathy associated with metastatic melanoma was successfully treated with an intravitreal dexamethasone implant. This localized therapy improved vision and retinal fluid, offering an alternative when systemic treatments are insufficient.
Area of Science:
- Ophthalmology
- Oncology
- Immunology
Background:
- Paraneoplastic vitelliform retinopathy is a rare condition causing retinal detachments.
- Metastatic cutaneous melanoma can present with ocular manifestations.
- Systemic immunotherapy has revolutionized melanoma treatment but can have ocular side effects.
