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Updated: May 13, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
[Revised consensus classification. Histopathological classification of diseases associated with joint endoprostheses]
V Krenn1, L Morawietz, H Kienapfel
1MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 5, 54296 Trier. krenn@patho-trier.de
Abstract:
The revised classification of the periprosthetic membrane (synovial-like interface membrane SLIM) encompasses all pathological alterations which can occur as a result of endoprosthetic replacement of major joints and lead to a reduction in durability of prostheses. This also includes the established consensus classification of SLIM by which aseptic and septic prosthetic loosening can be subdivided into four histological types and histopathological criteria for additional pathologies: endoprosthesis-associated arthrofibrosis, immunological/allergic alterations and osseous pathologies. This revision represents the foundation for the histopathological diagnostics of the total spectrum of diseases associated with joint prostheses, is a suitable basis for a standardized diagnostic procedure and etiological clarification of endoprosthesis failure and also as a data standard for endprosthesis registers, in particular for registers based on routine data (e.g. German endoprosthesis register).
Insights
A revised classification of the synovial-like interface membrane (SLIM) covers all pathological changes after joint replacement surgery. This update aids in diagnosing implant failure and standardizing data for joint replacement registers.
Area of Science:
- Orthopedic Surgery
- Pathology
- Biomaterials Science
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