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Updated: May 13, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
[Expression of CCAAT/enhancer binding protein beta in human gastric carcinoma and its clinical significance]
Yun-xia Du1, Lian-hai Zhang, Xiao-hong Wang
1Department of Gastrointestinal Cancer Surgery, Peking Cancer Hospital and Institute, Peking University Cancer Hospital, Beijing 100142, China.
Objective:
To explore the expression of CCAAT/enhancer binding protein beta (CEBPB) in gastric carcinoma tissues and its association with clinicopathological features and prognosis.
Methods:
CEBPB protein expression level was detected by immunohistochemistry method in resected gastric carcinomas and adjacent gastric mucosa tissues (n=81), and its association with clinicopathological features and prognosis was analyzed.
Results:
The immunohistochemical staining of CEBPB was predominantly in the nucleus with some cytoplasmic staining. As a result, 16% (13/81) of the gastric carcinomas were stained positively, whereas there was hardly positive expression in adjacent gastric mucosa tissues. There was a significant association between the expression of CEBPB and distant metastasis on univariate analysis (P<0.05). The median survival time in patients with positive CEBPB expression was significantly lower than those with negative CEBPB expression (19.4 months vs. 45.2 months, P=0.024). Multivariable analysis showed that CEBPB was independently associated with prognosis (HR=2.544, 95%CI:1.154-5.610, P=0.021).
Conclusion:
Up-regulation of CEBPB suggests poor prognosis in patients with gastric cancer.
