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Updated: May 13, 2026

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
Published on: March 18, 2021
[Cognitive development in Dravet's syndrome as a model of epileptic encephalopathy]
1Unidad de Neurología Infantil, Departamento de Pediatría, Clínica Universidad de Navarra, Avda. Pío XII 36, Pamplona, Navarre, Spain. rsanchezc@unav.es
Abstract:
Cognitive development in Dravet's syndrome is accompanied by a slowing or stagnation of the cognitive abilities during childhood. The fact that the syndrome is classified within the group of epileptic encephalopathies suggests that the epileptiform activity plays an important role in the genesis of the cognitive disorders. In this review it is shown that the epileptic phenotype and the critical and intercritical activity do not, by themselves, explain the cognitive development in children with Dravet's syndrome. Substantial changes in the treatment, with impact on cognitive development, will probably come with therapies that act by directly modifying the pathophysiology of the syndrome rather than its consequences.
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