Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Life01:23

Functions of Life

Human life is characterized by a variety of functions that are essential for survival and well-being. These functions include metabolism, movement, development, growth and reproduction.
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...
Intestinal Phase of Digestion01:29

Intestinal Phase of Digestion

The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Bioremediation00:46

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Mesenchymal Stromal Cell Immune Suppression Using Live Imaging in a Three-Dimensional Microfluidic Device.

ACS biomaterials science & engineering·2026
Same author

A microgel bone marrow model of mesenchymal stromal cell paracrine signaling supporting hematopoietic stem cell retention.

Acta biomaterialia·2026
Same author

Bone marrow-derived mesenchymal stromal cells yield greater pain relief and tissue protection than umbilical cord tissue-derived cells in a surgically induced instability model of osteoarthritis.

Osteoarthritis and cartilage·2026
Same author

Professor Xingdong Zhang Special Issue.

Tissue engineering. Part A·2026
Same author

Guiding Principles: Reporting Elements for Gastrointestinal Organoid Research.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Hydrogel Microdroplet Based Glioblastoma Drug Screening Platform.

Journal of biomedical materials research. Part A·2026
Same journal

Dual-Modal Phototherapeutic Nanoagents Eradicating Drug-Resistant Bacteria via Multi-Pathway of Membrane Disruption, Oxidative Damage, and Energy Metabolism Interference.

Advanced healthcare materials·2026
Same journal

Smartphone-Enabled Point-of-Care Biosensing Platform With Self-Calibration for Rapid Matrix-Resistant Detection of Multiple AMI Biomarkers in Whole Blood.

Advanced healthcare materials·2026
Same journal

Multimetal-Doped Nanoenzymes Reprogram Macrophages for Immunotherapy of Gouty Arthritis.

Advanced healthcare materials·2026
Same journal

Correction to "Fibrosis-on-Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease".

Advanced healthcare materials·2026
Same journal

A Collagen-based Scaffold Supports Tendon-to-bone Healing After Rotator Cuff Repair: An Integrated Translational Study.

Advanced healthcare materials·2026
Same journal

A Biomimetic Copper-Caffeic Acid Nanozyme Activates Cuproptosis and Pyroptosis by Mimicking the Neutrophil Enzymatic Cascade.

Advanced healthcare materials·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

In vivo Dual Substrate Bioluminescent Imaging
07:33

In vivo Dual Substrate Bioluminescent Imaging

Published on: October 11, 2011

Functional living biointerphases.

Anas Saadeddin1, Aleixandre Rodrigo-Navarro, Vicente Monedero

  • 1Abengoa Research, Abengoa, Campus Palmas Altas, Sevilla, Spain.

Advanced Healthcare Materials
|March 1, 2013
PubMed
Summary
This summary is machine-generated.

Scientists engineered Lactococcus lactis bacteria to display a fibronectin fragment on their surface. This living biomaterial interface can control cell behavior for advanced biomedical applications.

Keywords:
bacteriacell adhesionfibronectinintegrininterface

More Related Videos

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Bimolecular Fluorescence Complementation
08:54

Bimolecular Fluorescence Complementation

Published on: April 15, 2011

Related Experiment Videos

Last Updated: May 13, 2026

In vivo Dual Substrate Bioluminescent Imaging
07:33

In vivo Dual Substrate Bioluminescent Imaging

Published on: October 11, 2011

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Bimolecular Fluorescence Complementation
08:54

Bimolecular Fluorescence Complementation

Published on: April 15, 2011

Area of Science:

  • Biomaterials Science
  • Synthetic Biology
  • Cell Biology

Background:

  • Biomaterial surfaces require functionalization to guide cellular interactions.
  • Existing methods often lack dynamic control over surface properties.
  • Living systems offer unique possibilities for responsive biomaterial interfaces.

Purpose of the Study:

  • To develop a novel biomaterial surface functionalization strategy using a living system.
  • To engineer Lactococcus lactis to express a specific fibronectin fragment as a membrane protein.
  • To demonstrate the potential of this living interface for directing cell function.

Main Methods:

  • Genetic modification of Lactococcus lactis to express the fibronectin fragment FNIII₇₋₁₀.
  • Characterization of the engineered bacteria as a functional membrane protein display system.
  • Investigating the ability of the engineered interface to influence cell behavior.

Main Results:

  • Successful expression of the fibronectin fragment (FNIII₇₋₁₀) as a membrane protein in Lactococcus lactis.
  • Demonstration of the engineered bacteria as a living interface capable of presenting bioactive molecules.
  • Evidence that this system can provide spatio-temporal control over cell function.

Conclusions:

  • Lactococcus lactis can be engineered as a living platform for biomaterial surface functionalization.
  • This approach offers a new paradigm for creating dynamic and responsive biomaterial interfaces.
  • The technology holds significant promise for diverse biomedical applications requiring precise control of cell-material interactions.