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Updated: May 13, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes
Gang Xu1, Shaohua Gou, Chuanzhu Gao
1Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Abstract:
Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3-(2-amino-cyclohexylamino)-propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG-2, MCF-7, A549, and HCT-116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG-2 cell line. Particularly, complex X5, which has SO 4₂₋ as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis.

