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Updated: May 13, 2026

The (Spatial) Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
Published on: February 19, 2018
Spatial Learning and Memory-What's TLE Got To Do With It?
1Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Abstract:
Cognitive impairment is a significant comorbidity of epilepsy. At present, the molecular/cellular mechanisms that underlie these cognitive impairments remain unknown. It seems likely that a complete understanding at the molecular/cellular level will require the use of rodent models. A number of rodent models of epilepsy are used to study cognition in a variety of behavioral tasks. This review presents a brief overview of two commonly used tasks (the Morris water maze and the radial arm maze) that have been used to assess spatial learning/memory in two chemoconvulsant models of temporal lobe epilepsy.
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