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Updated: May 13, 2026
14:39
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Bioactive polyphenols from grapes and wine emphasized with resveratrol
Norbert Latruffe1, Jean-Pierre Rifler
1Université de Bourgogne. Laboratoire de Biochimie (Bio-PeroxIL), INSERM IFR100 - Faculté des Sciences, 6, Bd Gabriel, 21000 Dijon, France. latruffe@u-bourgogne.fr.
Current Pharmaceutical Design
|March 2, 2013
Summary
Grape-derived resveratrol, a potent antioxidant, shows promise for longevity and disease prevention in humans. Further research explores its synergistic effects with other grape polyphenols for enhanced health benefits.
Area of Science:
- Plant Science
- Nutritional Science
- Biochemistry
Background:
- Grape polyphenols, including resveratrol, are abundant in grapes and their by-products like wine.
- Resveratrol is recognized for its antioxidant properties, protecting low-density lipoproteins from oxidation.
- The "French paradox" highlights wine's potential preventive properties against vascular diseases.
Purpose of the Study:
- To review the pro-longevity properties of resveratrol in humans.
- To investigate potential synergies between resveratrol and other grape polyphenols.
- To bridge the gap between isolated molecule studies and the biological context of wine consumption.
Main Methods:
- Literature review on resveratrol's effects.
- Analysis of existing research on grape polyphenols and human health.
- Exploration of synergistic interactions between wine's complex polyphenol matrix.
Main Results:
- Resveratrol demonstrates preventive effects against infections, inflammation, neurodegenerative diseases, and cancer in experimental models.
- The review assesses the translation of these pro-longevity effects to the human species.
- Synergistic studies aim to understand combined effects of multiple polyphenols found in wine.
Conclusions:
- Resveratrol's pro-longevity potential in humans warrants further investigation.
- Understanding polyphenol synergies could lead to new dietary recommendations or supplements.
- Natural foods rich in polyphenols may offer significant health benefits.
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