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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Bipolar Disorder

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Related Experiment Video

Updated: May 13, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

The wnt pathway in mood disorders.

Gabriele Sani¹, Flavia Napoletano, Alberto Maria Forte

¹NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; Centro Lucio Bini, Rome, Italy.

Current Neuropharmacology

|March 2, 2013

Summary

Altered Wnt signalling may contribute to mood disorders, particularly bipolar and depressive disorders. Glycogen synthase kinase is key in bipolar disorder, while Wnt molecules in the hippocampus are linked to depression.

Keywords:

Antidepressant Drugs Antipsychotic Drugs.Bipolar Disorder Major Depression Mood Disorders Mood Stabilising Agents Wingless (Wnt) signalling

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Developing a Rat Model for Bipolar Disorder

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Last Updated: May 13, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

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Published on: June 6, 2025

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

Neuroscience
Molecular Biology
Psychiatry

Background:

The Wnt signalling pathway regulates crucial developmental and cellular processes.
Dysregulation of signalling pathways is implicated in the pathophysiology of mood disorders.

Purpose of the Study:

To review evidence on the Wnt signalling pathway's role in mood disorders.
To examine the Wnt pathway's involvement in the mechanisms of mood disorder treatments.

Main Methods:

Comprehensive PubMed search using Wnt pathway and mood disorder-related keywords.
Selection of relevant papers based on content and data for discussion.

Main Results:

Neurodevelopmental and behavioural data suggest Wnt pathway involvement in mood disorder pathophysiology.
Glycogen synthase kinase is identified as a key molecule in bipolar disorder.
Wnt molecules in the hippocampus are primarily implicated in depressive disorders.

Conclusions:

Altered Wnt signalling may play a role in mood disorder pathophysiology, but not a central one.
Further research is needed to determine the therapeutic potential of Wnt pathway manipulation in mood disorders.