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Published on: February 2, 2024
[Chemical constituents from Coptis chinensis]
Zhi-Feng Li1, Qi Wang, Yu-lin Feng
1National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine/Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. wangqilizhifeng@126.com
Summary
Seven chemical compounds were isolated from Coptis chinensis. Three of these compounds were identified for the first time in this plant, and one was new to the Coptis genus.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
Background:
- Coptis chinensis is a traditional medicinal herb.
- Understanding its chemical composition is crucial for its medicinal applications.
Purpose of the Study:
- To investigate and identify the chemical constituents present in the chloroform extract of Coptis chinensis.
Main Methods:
- Compounds were isolated using column chromatography.
- Structures of the isolated compounds were elucidated through spectroscopic analysis.
Main Results:
- Seven compounds were successfully isolated and identified.
- These compounds include worenine, 8,9-dihydroxy-1,5,6, 10b-tetrahydro-2H-pyrrolo[2,1-alpha] isoquinolin-3-one, (+/-)-5,5'-dimethoxy-lariciresinol, 3,4-dihydroxy-phenylethylalcohol, methyl-5-O-feruloylquinate, ethyl-5-O-feruloylquinate, and apocynol.
Conclusions:
- Compound (+/-)-5,5'-dimethoxy-lariciresinol is reported from the Coptis genus for the first time.
- Compounds methyl-5-O-feruloylquinate, ethyl-5-O-feruloylquinate, and apocynol are reported from Coptis chinensis for the first time.