Related Experiment Video
Updated: May 13, 2026
11:14
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Lymphoid proliferations associated with human immunodeficiency virus infection
Amy Chadburn1, Anmaar M Abdul-Nabi, Bryan Scott Teruya
1Department of Pathology, Northwestern University-Feinberg School of Medicine, Chicago, IL 60611, USA. achadburn@northwestern.edu
Archives of Pathology & Laboratory Medicine
|March 5, 2013
Summary
Individuals with immunodeficiency, including human immunodeficiency virus (HIV) infection, face a higher risk of lymphoproliferative disorders. This review details benign and malignant lymphoid proliferations in HIV, aiding classification and understanding lymphomagenesis.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Immunodeficient individuals have increased risk of lymphoproliferative lesions and lymphomas.
- Human immunodeficiency virus (HIV) infection is a key clinical setting for these disorders, as recognized by the World Health Organization (WHO).
Purpose of the Study:
- To categorize benign lymphoid proliferations and HIV-related lymphomas according to WHO.
- To discuss morphologic, immunophenotypic, and genetic features of these entities.
- To explore pathogenetic mechanisms of HIV-associated lymphoproliferations.
Main Methods:
- Review of WHO classification of hematopoietic and lymphoid tumors (2001, 2008).
- Literature search of PubMed.
- Analysis of published textbooks and institutional data.
Main Results:
- HIV infection is a recognized risk factor for lymphoproliferative disorders.
- Lymphomas in HIV are often aggressive B-cell types, but benign proliferations also occur.
- Classification of these disorders can be challenging.
Conclusions:
- HIV-associated lymphoproliferations, including benign types, can have significant clinical impact.
- Further research into these disorders enhances understanding of the immune system and lymphomagenesis.
- Accurate classification is crucial for patient management.
Related Concept Videos
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...