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Updated: May 13, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Recommendations for thromboprophylaxis in the 2012 focused update of the ESC guidelines on atrial fibrillation: a
1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK. g.y.h.lip@bham.ac.uk
Insights
The 2012 European Society of Cardiology guidelines for atrial fibrillation management emphasize identifying low-risk patients for stroke prevention. Patients with stroke risk factors should receive oral anticoagulation therapy.
Area of Science:
- Cardiology
- Stroke Prevention
- Atrial Fibrillation Management
Background:
- The 2012 European Society of Cardiology (ESC) guidelines provide focused updates on atrial fibrillation (AF) management.
- These guidelines advocate a shift in clinical practice for stroke prevention in AF patients.
- Advances in risk assessment and novel therapies have emerged since the 2010 guidelines.
Purpose of the Study:
- To provide a commentary on the 2012 ESC focused update recommendations for stroke prevention in AF.
- To evaluate the evidence supporting these recommendations.
- To discuss the practical implications of the updated guidelines.
Main Methods:
- Review and commentary on the 2012 ESC guidelines for AF.
- Analysis of the evidence base for stroke prevention strategies in AF.
- Discussion of novel oral anticoagulants (NOACs) and left atrial appendage occlusion (LAAO) devices.
Main Results:
- The guidelines recommend prioritizing the identification of 'truly low risk' patients who may not require antithrombotic therapy.
- Oral anticoagulation therapy (warfarin or NOACs) is recommended for AF patients with at least one stroke risk factor.
- Guidance is provided on stroke and bleeding risk assessment, NOACs, and LAAO devices.
Conclusions:
- The 2012 ESC guidelines promote a risk-stratified approach to stroke prevention in AF.
- Effective stroke prevention strategies, including oral anticoagulation, are crucial for AF patients with risk factors.
- The guidelines incorporate recent advancements in risk assessment and therapeutic options for AF management.
Abstract:
The objective of this article is to provide a commentary on the recommendations for stroke prevention from the 2012 focused update of the European Society of Cardiology guidelines on the management of atrial fibrillation and the evidence (or lack of it) supporting these recommendations. These guidelines strongly advocate a major clinical practice shift towards initially focusing on the identification of 'truly low risk' patients who do not need any antithrombotic therapy. After this initial decision-making step, effective stroke prevention - that is, oral anticoagulation therapy (whether as well-controlled adjusted dose warfarin or with one of the novel oral anticoagulants) - could be offered to patients with atrial fibrillation with ≥ 1 stroke risk factors. The 2012 focused update guideline also provides additional guidance on advances in stroke and bleeding risk assessment that are evident since publication of the 2010 guideline, as well as recommendations on the use of the novel oral anticoagulants and the left atrial appendage occlusion devices that have been increasingly used in European clinical practice over the last 2 years.
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