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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

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Published on: February 16, 2015

Down but not out.

James D Kim¹, Charlene Crockett, Orlando Diaz

¹Department of Ophthalmology, The University of Texas Medical Branch, Galveston, Texas.

Survey of Ophthalmology

|March 5, 2013

Summary

This summary is machine-generated.

A young man with Down syndrome experienced severe headaches and vision loss due to a rare dural arteriovenous fistula. Endovascular embolization successfully treated the condition, resolving his symptoms.

Keywords:

Onyx embolization cerebral venous sinus thrombosis dural arteriovenous malformation intracranial hypertension papilledema

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Area of Science:

Neurology
Vascular Surgery
Radiology

Background:

Down syndrome is associated with an increased risk of certain vascular abnormalities.
Dural arteriovenous fistulas (dAVFs) are abnormal connections between dura mater arteries and venous sinuses.
Cerebral venous sinus thrombosis can present with symptoms mimicking intracranial hypertension.

Observation:

A 20-year-old Hispanic male with Down syndrome presented with headache, decreased vision, and bilateral optic disk edema.
Magnetic resonance imaging revealed an empty sella and thrombosis of the left transverse and sigmoid sinuses.
Catheter angiography confirmed a dural arteriovenous fistula in the affected sinuses.

Findings:

Endovascular embolization using Onyx was performed to treat the dural arteriovenous fistula.
The procedure resulted in complete angiographic obliteration of the fistula.
The patient experienced resolution of his headache, vision changes, and optic disk edema.

Implications:

This case highlights a rare presentation of dural arteriovenous fistula in a patient with Down syndrome.
Endovascular embolization is an effective treatment for dural arteriovenous fistulas causing significant neurological symptoms.
Prompt diagnosis and intervention are crucial for favorable outcomes in complex vascular lesions.