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Related Experiment Videos

Perfusion imaging with NMR contrast agents.

B R Rosen1, J W Belliveau, J M Vevea

  • 1Department of Radiology, Massachusetts General Hospital, Boston 02114.

Magnetic Resonance in Medicine
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

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Magnetic Resonance (MR) contrast agents measure tissue perfusion by altering MR signal. Understanding contrast agent concentration and signal changes enables calculation of regional blood flow and volume.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biophysics
  • Medical Imaging

Background:

  • Regional hemodynamics is crucial for physiological research and clinical assessment.
  • Magnetic Resonance (MR) contrast agents are utilized to measure tissue perfusion.
  • Two key mechanisms, relaxivity and susceptibility effects, generate image contrast.

Purpose of the Study:

  • To review the application of MR contrast agents for measuring tissue perfusion.
  • To elucidate the relationship between contrast agent concentration and MR signal changes.
  • To explore the potential of contrast-enhanced NMR for in vivo physiological and anatomical mapping.

Main Methods:

  • Discussion of relaxivity effects (T1 and T2 rate enhancement).
  • Explanation of susceptibility effects (magnetic field variations due to contrast agents).

Related Experiment Videos

  • Analysis of the relationship between contrast agent concentration and MR signal changes.

    • Main Results:

    • Relaxivity effects primarily shorten T1 relaxation times.
    • A generally linear relationship exists between contrast agent concentration and rate change in most organs.
    • Tracer kinetic modeling can calculate regional blood flow and volume if the concentration-signal relationship is known.

    Conclusions:

    • Contrast-enhanced NMR is a feasible approach for in vivo mapping.
    • This technique offers potential for high-resolution mapping of physiology and anatomy.
    • Further understanding of dynamic contrast agent passage is needed.