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Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
Published on: March 15, 2024
Behavioural outcomes and psychopathology during adolescence
Samantha Johnson1, Dieter Wolke
1Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester, UK. sjj19@le.ac.uk
Abstract:
Preterm birth is associated with a high risk of residual neurodevelopmental disability and cognitive impairment. These problems are closely associated with psychiatric disorders and thus it is unsurprising that preterm birth also confers high risk for poor long term mental health. The risk associated with preterm birth is not a general one, but appears to be specific to symptoms and disorders associated with anxiety, inattention and social and communication problems, and manifest in a significantly higher prevalence of emotional disorders, ADHD and Autism. Adolescence is a key period for mental health and studies have shown that problems evident in childhood persist over this time and are more stable amongst preterm individuals than term-born peers. There is also modest evidence for an increased prevalence of psychotic symptoms in preterm adolescents. The high prevalence of psychiatric disorders, present in around 25% of preterm adolescents, requires long term screening and intervention.
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