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Updated: May 13, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Malignant pleural mesothelioma forming a huge mediastinal mass and causing atrial fibrillation
Hiroko Kuwabara1, Hiroshi Tsuji, Yuki Inada
1Department of Pathology, Osaka Medical College, Osaka, Japan.
Abstract:
A patient with malignant pleural mesothelioma was admitted with atrial fibrillation. Chest computed tomography showed a huge mediastinal tumor adjacent to the heart. Autopsy revealed a 12×9.5-cm mediastinal mass involving the right lung, which distorted and stretched the myocardial sleeve surrounding the right inferior pulmonary vein. This case demonstrates that advanced malignant pleural mesothelioma can cause atrial fibrillation, possibly by stimulating myocardium around a pulmonary vein.
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