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Related Experiment Videos

MRI in familial multiple sclerosis.

S G Lynch1, J W Rose, W Smoker

  • 1Department of Neurology, University of Utah Medical School, Salt Lake City.

Neurology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

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Subclinical multiple sclerosis (MS) may be present in seemingly healthy relatives of MS patients. Cranial MRIs revealed white matter lesions in some normal family members, suggesting early or undiagnosed MS.

Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Multiplex families, where MS occurs in multiple members, offer insights into genetic and environmental factors.
  • Identifying subclinical disease is crucial for early intervention.

Purpose of the Study:

  • To investigate the prevalence of brain abnormalities suggestive of demyelination in apparently normal family members of individuals with MS.
  • To determine if subclinical MS lesions are detectable via cranial MRI in unaffected relatives.

Main Methods:

  • Cranial magnetic resonance imaging (MRI) was performed on 76 individuals from 13 MS multiplex families.
  • Participants included 31 individuals diagnosed with MS and 45 neurologically normal family members.

Related Experiment Videos

  • MRI findings were analyzed for the presence and characteristics of white matter lesions.

    • Main Results:

    • Twenty-eight of 31 MS patients exhibited multiple white matter lesions.
    • Ten of 45 normal family members had abnormal MRIs, including white matter lesions.
    • Abnormal MRIs in normal individuals under 40 were particularly suggestive of demyelination.

    Conclusions:

    • Subclinical multiple sclerosis (MS) may be present in asymptomatic members of MS multiplex families.
    • Cranial MRI can detect white matter lesions indicative of demyelination in individuals without a clinical MS diagnosis.
    • These findings highlight the potential for early detection and intervention in at-risk family members.