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Related Experiment Videos

Optic neuritis: a prospective study.

G G Celesia1, D I Kaufman, M Brigell

  • 1Department of Neurology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL 60153.

Neurology
|June 1, 1990
PubMed
Summary
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Acute optic neuritis patients showed significant visual recovery within 6 months. Initial visual impairment grading using the GVIS scale predicted long-term outcomes, with prolonged VEP latency indicating resolved optic neuritis.

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Acute optic neuritis is an inflammatory condition affecting the optic nerve.
  • Visual function deficits are common in acute optic neuritis.

Purpose of the Study:

  • To prospectively evaluate visual recovery in patients with acute optic neuritis over 12 months.
  • To assess the utility of a novel Graded Visual Impairment Scale (GVIS) in predicting outcomes.
  • To determine the role of Visual Evoked Potentials (VEPs) in monitoring recovery.

Main Methods:

  • Prospective study of 20 patients with acute optic neuritis for 12 months.
  • Comprehensive visual function testing including visual fields, color vision, visual acuity, and contrast sensitivity.
  • Development and application of the Graded Visual Impairment Scale (GVIS).

Related Experiment Videos

  • Recording of Visual Evoked Potentials (VEPs).

    • Main Results:

    • All patients initially presented with abnormal visual fields, color vision, and VEPs.
    • 90% had abnormal visual acuity and 95% had abnormal contrast sensitivity.
    • 65% of patients achieved complete visual recovery, with most recovery occurring within 2 months.
    • Initial GVIS classification strongly correlated with final visual outcome.
    • Prolonged VEP latency persisted in 19 patients despite normal visual function, indicating resolved optic neuritis.

    Conclusions:

    • Complete visual recovery is common in acute optic neuritis, often occurring rapidly.
    • The GVIS is a valuable tool for predicting visual prognosis in acute optic neuritis.
    • VEP latency is a reliable indicator of optic nerve recovery even after visual function normalizes.