Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and Outcomes of Refractory Septic Shock per Consensus Clinical Criteria: A Multicohort Retrospective Study.

Critical care medicine·2026
Same author

ABC'S of AI: proposing a clinician's framework for the interpretation of artificial intelligence studies.

Frontiers in medicine·2026
Same author

Evaluating Phosphorus Sorption and Desorption in Agricultural Wastewater Using Designer Biochar Pellets.

Water environment research : a research publication of the Water Environment Federation·2026
Same author

Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Critical care medicine·2026
Same author

Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Intensive care medicine·2026
Same author

The Devil Is in the Details: Sustaining First-Case On-Time Starts at a Quaternary Care Center.

Journal for healthcare quality : official publication of the National Association for Healthcare Quality·2026
Same journal

A 20-year-old woman with a 9-year history of shortness of breath.

Cleveland Clinic journal of medicine·2026
Same journal

A 70-year-old man with lower-extremity weakness and falls.

Cleveland Clinic journal of medicine·2026
Same journal

Treatment-refractory hypothyroidism: Don't just increase the dose.

Cleveland Clinic journal of medicine·2026
Same journal

In Reply: Beyond histologic improvement in MASH.

Cleveland Clinic journal of medicine·2026
Same journal

Comfort care: Creating a plan for hospitalized patients and their families.

Cleveland Clinic journal of medicine·2026
Same journal

Localized dead bone, a potential hint to an underlying condition.

Cleveland Clinic journal of medicine·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

Septic shock: the initial moments and beyond.

Simon W Lam1, Seth R Bauer, Jorge A Guzman

  • 1Department of Pharmacy, Cleveland Clinic, Cleveland, OH 44195, USA. lams@ccf.org

Cleveland Clinic Journal of Medicine
|March 5, 2013
PubMed
Summary
This summary is machine-generated.

Recent advances in sepsis management, including evidence-based protocols, have improved patient outcomes. This review covers initial and later sepsis treatment strategies, highlighting areas of ongoing research and discussion.

More Related Videos

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Related Experiment Videos

Last Updated: May 13, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Emergency Medicine

Background:

  • Sepsis pathophysiology and treatment understanding has significantly evolved.
  • Evidence-based protocols have demonstrably improved sepsis outcomes.
  • Effective sepsis management requires timely and appropriate interventions.

Purpose of the Study:

  • To review the current management strategies for sepsis.
  • To discuss sepsis treatment in the initial hours and subsequent phases.
  • To highlight ongoing research and debated topics in sepsis care.

Main Methods:

  • Literature review of recent advancements in sepsis management.
  • Synthesis of evidence-based protocols for sepsis treatment.
  • Analysis of current therapeutic approaches and future research directions.

Main Results:

  • Sepsis management has advanced, leading to better patient outcomes.
  • Established protocols guide effective early and late-stage sepsis care.
  • Several areas in sepsis pathophysiology and treatment remain under active investigation.

Conclusions:

  • Continued adherence to evidence-based protocols is crucial for optimal sepsis outcomes.
  • Understanding evolving sepsis pathophysiology informs treatment advancements.
  • Ongoing research is vital for addressing debated aspects of sepsis management.