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Related Experiment Video

Updated: May 13, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Characterization of printable cellular micro-fluidic channels for tissue engineering.

Yahui Zhang1, Yin Yu, Howard Chen

  • 1Mechanical and Industrial Engineering Department, The University of Iowa, Iowa City, IA, USA.

Biofabrication
|March 6, 2013
PubMed
Summary

Researchers developed printable, hollow microfluidic channels using a novel fabrication platform. This advancement supports cell viability and function, offering a promising solution for vascularized tissue engineering and organ fabrication.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Organ shortage necessitates advanced tissue engineering solutions.
  • Creating vascular networks for nutrient/oxygen perfusion in 3D tissues is a major challenge.
  • Existing methods struggle to integrate functional vasculature into engineered tissues.

Purpose of the Study:

  • To develop a novel method for fabricating printable, hollow microfluidic channels for 3D tissue engineering.
  • To investigate the manufacturability and structural integrity of these channels.
  • To assess cell viability and function within the fabricated channels.

Main Methods:

  • Development of a pressure-assisted solid freeform fabrication platform with a coaxial needle dispenser.
  • Printing of hollow hydrogel filaments with controlled rheology and material properties.

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Last Updated: May 13, 2026

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A Microfluidic Device with Groove Patterns for Studying Cellular Behavior
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  • Encapsulation of cartilage progenitor cells (CPCs) within alginate hollow filaments.
  • Evaluation of cell viability and gene expression using in vitro culture and real-time PCR.

    • Main Results:

    • Successful fabrication of printable, hollow microfluidic channels capable of fluid transport and mechanical support.
    • Cartilage progenitor cells (CPCs) demonstrated high viability post-bioprinting and during culture.
    • Encapsulated CPCs showed enhanced expression of cartilage-specific genes compared to monolayer cultures.
    • Printable semi-permeable microfluidic channels provide a supportive microenvironment for cell growth and function.

    Conclusions:

    • The developed fabrication platform enables the creation of functional, hollow microfluidic channels for tissue engineering.
    • Printable microfluidic channels support cell viability and promote specific cell functions.
    • This technology holds potential for fabricating vascularized 3D tissues and organs.