Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 13, 2026

High-Definition Transcranial Direct Current Stimulation During Sleep
09:23

High-Definition Transcranial Direct Current Stimulation During Sleep

Published on: December 5, 2025

Transcranial electrical stimulation accelerates human sleep homeostasis.

Davide Reato1, Fernando Gasca, Abhishek Datta

  • 1Department of Biomedical Engineering, The City College of the City University of New York, New York, New York, USA. davide.reato@gmail.com

Plos Computational Biology
|March 6, 2013
PubMed
Summary

Transcranial electrical stimulation reduced the decay of slow-wave oscillations during sleep. This suggests electrical stimulation accelerates synaptic homeostasis, impacting sleep architecture and brain function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.

Journal of medicinal chemistry·2026
Same author

Effects of antidepressants, anesthetics and sedatives/hypnotics on sleep-associated memory consolidation - A systematic review.

Journal of psychopharmacology (Oxford, England)·2026
Same author

Development and Testing of a Transcutaneous Electrical Nerve Stimulation Device for Pilots.

Military medicine·2026
Same author

Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.

Frontiers in sleep·2026
Same author

Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos.

Scientific data·2026

Area of Science:

  • Neuroscience
  • Sleep Science
  • Computational Modeling

Background:

  • The sleeping brain shows decaying slow-wave activity (SWA) throughout the night, linked to synaptic downscaling.
  • Transcranial electrical stimulation (TES) can influence slow-wave oscillations (SWO) in human electroencephalography (EEG).

Purpose of the Study:

  • To investigate the effect of TES on synaptic homeostasis during sleep.
  • To determine if TES-induced changes in firing rates accelerate synaptic downscaling.

Main Methods:

  • Applied 25 minutes of TES to human participants.
  • Measured EEG to assess SWO decay.
  • Used anatomically accurate computational models to simulate electrical field intensities and their effects on cortical activity.

More Related Videos

Transcranial Electrical Brain Stimulation in Alert Rodents
10:08

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

Related Experiment Videos

Last Updated: May 13, 2026

High-Definition Transcranial Direct Current Stimulation During Sleep
09:23

High-Definition Transcranial Direct Current Stimulation During Sleep

Published on: December 5, 2025

Transcranial Electrical Brain Stimulation in Alert Rodents
10:08

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

Main Results:

  • TES significantly reduced the decay of SWO in the latter part of the night.
  • Simulated field intensities on the human cortex accurately predicted the observed effect sizes across different EEG electrodes.
  • The findings align with the hypothesis that increased firing rates during stimulation accelerate synaptic downscaling.

Conclusions:

  • TES can modulate sleep architecture by influencing synaptic homeostasis.
  • A mechanistic link exists between electrical brain stimulation and accelerated synaptic downscaling during human sleep.
  • Computational models are valuable for understanding the precise effects of TES on brain activity.