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Updated: May 13, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Convenient Synthesis of Multivalent Zinc(II)-Dipicolylamine Complexes for Molecular Recognition
Shuzhang Xiao1, Serhan Turkyilmaz, Bradley D Smith
1Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
Abstract:
A pair of novel dipicolylamine ligands bearing isothiocyanate groups were used as conjugation reagents to prepare multivalent molecules with anionic recognition capability. The isothiocyanates were reacted with two classes of dendritic scaffolds bearing primary amines, squaraine rotaxanes and PAMAM dendrimers, and the products were converted into water soluble zinc(II) coordination complexes. The multivalent squaraine rotaxanes exhibit high fluorescence quantum yields in water and are very well suited for biological imaging applications.
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