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Updated: May 13, 2026

06:51
Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
Published on: May 6, 2020
Resolving DNA at efficiencies of more than a million plates per meter using bare narrow open capillaries without
Zaifang Zhu1, Lei Liu, Wei Wang
1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Abstract:
We report a novel approach for effectively separating DNA molecules in free solution. The method uses a bare narrow open capillary without any sieving matrices to resolve a wide size-range of DNA fragments at efficiencies of more than a million plates per meter routinely.

